ISSN 1662-4009 (online)

ey0019.15-6 | New Hormones | ESPEYB19

15.6. A hormone complex of FABP4 and nucleoside kinases regulates islet function

KJ Prentice , J Saksi , LT Robertson , GY Lee , KE Inouye , K Eguchi , A Lee , O Cakici , E Otterbeck , P Cedillo , P Achenbach , AG Ziegler , ES Calay , F Engin , GS Hotamisligil

Nature. 2021;600(7890):720-6. doi: 10.1038/s41586-021-04137-3.PubMed ID: 34880500Brief summary: This mouse study identifies FABP4 (‘Fabkin’) as a new fat-derived hormone that regulates insulin-producing beta cells in the pancreas.We have learnt over the recent years that body fat is not simply a passive energy storage tissue, but instead secretes a number o...

ey0018.3-1 | Mechanism of the year | ESPEYB18

3.1. Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident

LM Morton , DM Karyadi , C Stewart , TI Bogdanova , ET Dawson , MK Steinberg , J Dai , SW Hartley , SJ Schonfeld , JN Sampson , YE Maruvka , V Kapoor , DA Ramsden , J Carvajal-Garcia , CM Perou , JS Parker , M Krznaric , M Yeager , JF Boland , A Hutchinson , BD Hicks , CL Dagnall , JM Gastier-Foster , J Bowen , O Lee , MJ Machiela , EK Cahoon , AV Brenner , K Mabuchi , V Drozdovitch , S Masiuk , M Chepurny , LY Zurnadzhy , M Hatch , A Berrington de Gonzalez , GA Thomas , MD Tronko , G Getz , SJ Chanock

Science. 2021;372(6543):eabg2538. doi: 10.1126/science.abg2538.Radioactive iodine (131I)-exposed children in the region of Chernobyl (Ukraine) showed an increased incidence of papillary thyroid carcinoma (PTC) after the 1986 nuclear plant accident [1]. This so far the largest and most comprehensive study to characterize the genomic landscape of radiation induced PTC in a large n...